Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Lys-bradykinin TFA | 00-00-0 | 99.9% | 1188.38 g/mol (free base) | C56H85N17O12 · xC2HF3O2 | 25 MG
Lys-bradykinin TFA is the trifluoroacetate salt form of the decapeptide kallidin (Lys-bradykinin). It is used as a research reagent and acts as a ligand for kallidin and bradykinin receptors, supporting studies in vascular regulation, inflammation, and pain signaling.
- TFA salt form of lys-bradykinin (kallidin).
- High purity (≈99.85%).
- Molecular weight 1188.38 g/mol (free base).
- Provided in small quantities suitable for biochemical assays; 25 mg size available.
- Intended for receptor binding and vascular biology research applications.
Medchemexpress LLC Ile-AMS TFA | 219931-45-0 | MFCD31619268 | 98.6% | 572.52 g/mol | C18H27F3N8O8S | 10 MG
Ile-AMS TFA is the trifluoroacetic acid (TFA) salt of an aminoacyl-sulfamoyl adenosine analogue that inhibits isoleucyl-tRNA synthetase and displays potent antiparasitic activity (P. falciparum ABS IC50 = 1.19 nM). Intended for laboratory research use only.
- Purity 98.55%.
- Molecular weight 572.52 g/mol; chemical formula C18H27F3N8O8S.
- Soluble in water (≈100 mg/mL); ultrasonic assistance may be required.
- Recommended storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
- Available in small research quantities, including a 10 mg package.
- Used as a tool compound for studies of aminoacyl-tRNA synthetase inhibition and antiparasitic research.
Waters Corp Proteomics Training Standards, Kit
Waters Corporation Proteomics Training Standards, Kit
Selleck Chemical LLC Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable competitive and irreversible inhibitor of enzyme caspase-9 which helps in cell survival
Apexbio Technology LLC Pyrophosphatase Inorganic (E. coli) 10 units
Pyrophosphatase Inorganic (E coli) purified from recombinant E coli strain carrying the E coli inorganic pyrophosphatase gene Inorganic pyrophosphatase (PPase) is a ubiquitous enzyme that catalyzes the hydrolysis of inorganic pyrophosphate into orthophosphate
Medchemexpress LLC PD1-PDL1-IN 1 TFA | 2005454-12-4 | >99.5% | 385.38 g/mol | C14H23N7O6 | 1 ML
PD1-PDL1-IN 1 TFA is a small-molecule programmed cell death 1 (PD-1) inhibitor supplied as the trifluoroacetic acid (TFA) salt for research use. It is intended for use as an immune-modulating reagent in PD-1/PD-L1 pathway studies, screening, and preclinical laboratory assays.
- Potent PD-1 inhibition useful for pathway and mechanism studies.
- Supplied as a TFA salt to aid solubility and handling.
- Characterized with published CAS and molecular data for identification.
- Suitable for compound screening and preclinical research applications.
- Available in small research-scale formats for laboratory use.
Medchemexpress LLC CH-0793076 TFA (TP3076 TFA) | 2740278-76-4 | 98.7% | 572.53 g·mol⁻¹ | C28H27F3N4O6 | 5 MG
CH-0793076 TFA is a camptothecin-like hexacyclic analog and the active metabolite of TP300 that functions as a DNA topoisomerase I inhibitor. It is supplied as a trifluoroacetate salt for research use and has demonstrated antiproliferative activity, including activity against cells expressing BCRP.
- Inhibits DNA topoisomerase I (reported IC50 ≈ 2.3 μM).
- Active metabolite of TP300.
- Demonstrates antiproliferative activity in cellular assays.
- Provided as a trifluoroacetate salt suitable for biochemical studies.
- Molecular weight 572.53 g·mol⁻¹; chemical formula C28H27F3N4O6.
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g·mol⁻¹ | C34H49F3N4O10 | 25 MG
Alvespimycin trifluoroacetate (17-DMAG TFA) is the trifluoroacetic acid salt of a semisynthetic geldanamycin derivative that potently inhibits Hsp90. It binds Hsp90 in the low-nanomolar range and is used in cellular and biochemical studies to induce heat-shock response and promote degradation of Hsp90 client proteins, supporting research into proteostasis and targeted oncology pathways.
- Potent Hsp90 inhibition with reported EC50 ≈ 62 nM.
- Promotes Her2 degradation in cancer cell lines (EC50 8 nM in SKBR3, 46 nM in SKOV3).
- Induces Hsp70 expression in cell assays (EC50 4 nM in SKBR3, 14 nM in SKOV3).
- High purity (>98.9%) suitable for in vitro studies.
- Available in small research pack sizes, including 25 MG.
Medchemexpress LLC PLP (180-199) TFA | 99.22% | 2085.34 (free base) | 1 MG
PLP (180-199) TFA is the TFA salt form of PLP (180-199). It induces the activation and differentiation of T cells and induces experimental autoimmune encephalomyelitis (EAE) in mouse models.
- Activates and differentiates T cells
- Induces experimental autoimmune encephalomyelitis (EAE) in mouse models
- Molecular weight: 2085.34 (free base)
- Purity: 99.22%
- Sealed storage, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
