Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 10mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways
Medchemexpress LLC Gplgiagq tfa | 99.9% | 825.83 | 50 MG
GPLGIAGQ TFA is an MMP2-cleavable polypeptide used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. It can also be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT). This product is for research use only.
- Used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for tumor targeting
- Can be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT)
- For research use only
- MMP2-cleavable polypeptide
- Target: MMP2
- Molecular weight: 825.83
- Formula: C33H54F3N9O12
- Appearance: solid, white to off-white
- Sequence: Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln
Medchemexpress LLC VU0364572 TFA | 1240514-89-9 | 99.3% | 487.51 | 1 ML
VU0364572 TFA is an orally active, selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Acts as an orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Features an EC50 of 0.11 μM.
- Demonstrates neuroprotective potential.
- Aids in preventing memory impairments and reducing neuropathology in Alzheimer's Disease.
- Is CNS penetrant.
Medchemexpress LLC Mi-1061 Tfa | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 25MG
MI-1061 TFA is the trifluoroacetate (TFA) salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 protein-protein interaction. It activates p53, induces apoptosis in tumor models, and shows selective activity in p53 wild-type cell lines.
- Potent biochemical MDM2-p53 interaction inhibitor (IC50 = 4.4 nM; Ki = 0.16 nM).
- Selective cellular activity with IC50 = 100 nM in SJSA-1 and 250 nM in HCT-116 p53+/+; >10,000 nM in p53-/- cells.
- Trifluoroacetate salt presented as a solid form.
- Molecular weight 696.47 and molecular formula C32H27Cl2F4N3O6.
- Intended for research use as a tool compound to study p53 activation and antitumor effects.
- Purity listed as 97.47%.
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 5 MG
SJ1008030 TFA is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be utilized for leukemia research. The compound is composed of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selective JAK2 PROTAC degrader.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Can be used for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC Cpn-267 tfa | 1279.27 | 1 MG
Cpn-267 tfa is a selective agonist for neuromedin U receptor 1 (NMUR1) with an EC50 of 0.25 nM. This compound has been shown to suppress body weight gain in mice, suggesting its potential use in the study of obesity. It is provided as a solid for research applications.
- Selective NMUR1 agonist.
- Potent activity at nanomolar concentrations.
- Demonstrated suppression of body weight gain in animal models.
- Suitable for obesity research.
Medchemexpress LLC 7-TFA-ap-7-Deaza-dA | 178420-75-2 | 98.8% | 399.32 | 1 ML
7-TFA-ap-7-Deaza-dA is a modified nucleoside that can be used in the synthesis of deoxyribonucleic acid or nucleic acid. It functions as a click chemistry reagent, containing an alkyne group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Modified nucleoside.
- Can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
- Functions as a click chemistry reagent.
- Contains an alkyne group for reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC LL-37 amide TFA | 99.3% | 4492.28 | 10 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effective in inhibiting periodontal pathogens. It functions by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. This modified form of LL-37 also regulates inflammatory responses, promotes angiogenesis, and shows improved stability and enhanced resistance to enzymatic degradation compared to natural LL-37.
- Effective against periodontal pathogens
- Activates FPRL1-mediated immune cell chemotaxis
- Disrupts bacterial cell membrane integrity
- Regulates inflammatory responses and promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Good antibacterial effects against Gram-positive and Gram-negative bacteria
- Used in research for infection-related diseases and wound healing
Medchemexpress LLC ATX-II (TFA) | 99.65% | 4934.62 (free acid) | 100 UG
ATX-II TFA is a selective sodium channel modulator toxin that enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. This compound exhibits a pro-arrhythmic effect by slowing intrinsic heart rate, prolonging the QT interval and sinus node recovery time, and inducing sinus pauses and arrests. It is suitable for research related to atrial fibrillation, long QT syndrome, and long QT3 syndrome.
- Enhances tetrodotoxin sensitive resurgent and persistent sodium currents in large diameter mouse DRG neurons.
- Shifts the voltage dependence of activation and steady-state fast inactivation of TTXS sodium channels to more hyperpolarized potentials.
- Increases diastolic tension and arrhythmia score in isolated rat right atrial tissue.
- Significantly increases diastolic intracellular Ca2+ concentrations in isolated rat atrial myocytes.
Covachem Trifluoroacetic Acid | 76-05-1 | MFCD00004169 | 10 x 1 mL
This item has a minimum order quantity of 2 per supplier requirements.
Trifluoroacetic Acid | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL
Apexbio Technology LLC 2X hyperfusion plus master mix (With dye) 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb 2X Hyperfusion plus master mix (With dye) is a ready-to-use 2 premix solution containing polymerase dNTPs an already optimized buffer system and dye Our mix is ideal for any detection and the PCR product can be directly electrophoresed after the amplification without the need to add a loading buffer
Medchemexpress LLC SsK36 TFA | 99.3% | 1771.04 (free base) | 5 MG
ssK36 TFA is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2). It is designed for the SETD2 protein, a specific PKMT, responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. This peptide can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36 and can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency.
- Purity of 99.34%
- Molecular weight of 1771.04 (free base)
- Formula: C79H127N29O18.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Sequence: Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro
- Sequence shortening: APRFGGVKRPNRYRP
- Solubility (in vitro): 1 mg/mL in H2O (requires ultrasonic)
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 25 MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects.
- Induces mitochondrial alterations
- ROS generation
- Intracellular Ca+ accumulation
- Calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells through immunogenic cell death
Medchemexpress LLC PLP (180-199) TFA | 99.22% | 2085.34 (free base) | 1 MG
PLP (180-199) TFA is the TFA salt form of PLP (180-199). It induces the activation and differentiation of T cells and induces experimental autoimmune encephalomyelitis (EAE) in mouse models.
- Activates and differentiates T cells
- Induces experimental autoimmune encephalomyelitis (EAE) in mouse models
- Molecular weight: 2085.34 (free base)
- Purity: 99.22%
- Sealed storage, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)